外伤性脑梗塞患者C反应蛋白的变化及他汀类药物对其干预

The Total C-reactiveprotein Concentration in the Patients with Traurnatic Cerebral Infarction and Intervention Study

目的观察外伤性脑梗塞患者C反应蛋白（CRP）的异常，并应用他汀类药物治疗，探讨其对CRP的干预。方法选择在我院符合外伤性脑梗塞诊断标准的58例，门诊志愿者正常人55例，分别测定血CRP浓度进行比较；再将外伤性脑梗塞组再分为氟伐他汀治疗组、常规治疗组两组，对照组均接受脑活素、低分子右旋糖酐加复方丹参注射液等常规治疗，治疗组在此基础上加服氟伐他汀，再对常规治疗及加入他汀类药物治疗后CRP水平进行比较。结果治疗外伤性脑梗塞患者与正常人CRP水平比较有显著性差异（P〈0．01），外伤性脑梗塞患者应用他汀类治疗较常规治疗后CRP水平显著下降（P〈0．01）。结论CRP做为炎症的一种敏感性介质，其介导的补体激活在外伤性脑梗塞形成中具有一定的作用，故外伤性脑梗塞患者血CRP浓度显著升高。氟伐他汀做为HMA-CoA还原酶抑制剂除具有调脂作用外，还有抗炎作用，可显著降低外伤性脑梗塞患者血浆CRP水平，故他汀类降脂药在改善外伤性脑梗塞预后、预防脑血管急性事件发生有重要作用。

Objective To investigate total serum CRP concentration in traurnatic cerebral infarction patients in comparison with normal control elders and to evaluate whether providing fluvastatin could decrease serum CRP concentration. Methods 58 TCI patients were randomly divided into two groups： group A as control, group B treated with fluvastatin. The levels of blood 1CRP were measured before and 3 weeks after the treatment .Results The serum level of CRP significantly decreased in group A and group B, with have significant difference in effect between group B. Conclusions The treatment with fluvastatin can decrease the serum CRP levels in patients with traumatic cerebral infarction, both of which have a beneficial effect of antiinflammation and stabilizing.