未经干预的糖耐量受损患者动态血糖的特点

Continuous Blood Glucose Monitoring in Patients with Impaired Glucose Tolerance

目的动态监测糖耐量受损(IGT)患者血糖波动及漂移趋势。方法采用动态血糖监测系统(CGMS)对58例未经干预治疗的IGT患者进行连续72h的血糖监测。结果患者一天中血糖较低的时间段为夜间3点,以后血糖逐渐升高,进餐后2h血糖漂移至最高峰值,一天内血糖高于7.8及11.1mmol/L所占的时间构成比分别为(13.3±11.1)/和(0.3±1.2)/。一天内血糖最高与最低值的差值为(4.4±1.3)mmol/L。日内平均血糖波动幅度为(4.86±0.19)mmol/L。日间血糖平均绝对差为(1.09±0.06)mmol/L。平均血糖水平与HbA1C及指端毛细血管血糖值呈显著正相关(r值分别为0.86,0.89,均P<0.01)。结论动态血糖监测能详细显示IGT患者血糖波动及漂移趋势的特征,可对拟定干预治疗方案提供依据。

Objective To investigate the fluctuation and excursion of blood glucose in patients with impaired glucose tolerance （IGT）. Methods The fluctuations of glucose levels in 58 unintervened IGT patients were measured by continuous blood glucose monitoring system （CGMS） for 72 hours. Results The glycemie excursions revealed that the daily glycemic levels were lower at 3 AM, the climax of daily glycemic level tended to appear at 2 hours after meals. The glycemic profiles showed that the proportion of time for hyperglycemia above 7.8 and 11.1mmol/L accounted for （13.3±11.1）% and （0.3±1.2）%, respectively. The magnitude of glycemic excursions were （4.4±1.3） mmol/L for 24 hours. The CGMS values in this study was significantly correlated with HbAlc （r=0.86, P〈0.01）. Conclusion The glycemic excursions of IGT patients can be measured by CGMS in detail and may have beneficial effects in IGT intervention.