1Meunier JC,Mollerau C,Toll L,et al.Isolation and structure of the endogenous agonist of opioid receptor[J].Nature,1995,377(1):532-533.
2Champion HC,Czapla MA,Kadowitz PJ.Nociceptin,an endogenous ligand for the ORL1 receptor,decreases cardiac output and total peripheral resistance in the rat[J].Peptides,1997,18(5):729-732.
3Kobayashi T,Ikeda K,Togashi S,et al.Effects of sigma ligands on the nociceptin/orphanin FQ receptor co-expressed with the G-protein-activated K+ channel in Xenopus oocytes[J].Br J Pharmacol,1997,120(6):986-987.
3[4]Kapusta DR, Dayan LA, Kenigs VelgaA. Nociceptin/orphanin FQ modulates the cardiovascular, but not renal, responses to stress in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol,2002, 29: 254 ～ 259.
4[5]Taylor F, Dickenson A. Nociceptin Lorphanin FQ.A new opioid, a new analgesic? Neuroreport,1998, 9:65～70.
5[6]Grisel JE, Mogil JS. Effects of supraspinal orphanin FQ/nociceptin. Peptides, 2000, 21 : 1037 ～1045.
6[7]Suaudeau C, Florin S, Meunier JC, et al . Nociceptin-induced apparent hyperalgesia in mice as a result of the prevention of opioid autoanalgesic mechanisms triggered by the stress of an intracerebroventricular injection. Fundam Clin Pharmacol,1998, 12: 420 ～425.
7[8]Rizzi A, Bigoni R, Marzola G, et al. The nociceptin/orphanin FQ receptor antagonist, [Nphe1] NC (1-13) NH2, potentiates morphine analgesia. Neuroreport, 2000, 11 : 2369 ～ 2372.
8曹泽毅.中华妇产科学[M](第1版)[M].北京:人民卫生出版社,1999.474-476.
9Neal CR, Mansour A, Reinscheid R,et al. Localization of orphanin FQ(nociceptin) peptide and messenger RNA in the central nervous system of the rat[J]. J Comp Neurol, 1999, 406(4) : 503-547.
10Neal CR, Mansour A, Reinseheid R,et al.Opioid receptor-like(ORL1) receptor distribution in the rat central nervous system:comparison of ORL1 receptor mRNA expression with(125)I-[ ( 14 ) Tyr ] -orphanin OFQ binding [ J ].J Comp Neurol,1999,412(4):563-605.
