稀土元素钐对小鼠学习记忆的影响及其脑内机制

Effects of samarium nitrate on learning-memory of mice and its mechnism

采用行为观察和生化检测相结合的方法,研究了小鼠长期饮用不同剂量的硝酸钐溶液对其学习记忆力、脑内单胺类神经递质含量及一氧化氮合成酶(NOS)活力的影响.结果表明:随着硝酸钐浓度的增高,小鼠的学习记忆能力下降,脑内多巴胺(DA)和5-羟基色胺(5-HT)含量减少,NOS活性降低.提示饮用50 mg/L的硝酸钐溶液对小鼠的学习记忆能力有明显的损伤作用,而且这种作用可能与脑内单胺类神经递质含量的降低和一氧化氮合成酶活力的降低有关.

The effects of samarium nitrate on learning-memory of mice, the content of monoaminergic neurotransitter, and the activity of NOS in the brain of mice were investigated through behavior observation and biochemistry analysis after Sm （ NO3 ） 3 of different concentrations were administered to mice for three months. Compared with control group, the results were as follows ： the learning-memory ability of mice were decreased, the contents of dopamine and 5-hydroxytryptamine were descented, and the activity of NO synthetic enzyme were abated along with the concentrations of Sm increasing in the mice＇s brain. It implied that Sm（NO3）3 in the concentration of 50 mg/L can make apparent effect on the function of brain , which may be related with decrease of content of monoaminergic neurotransitter and the activity of NOS of the brain.