甲基丙烯酸环氧丙酯慢性毒性的研究

STUDY ON CHRONIC TOXICITY OF GLYCIDYL METHACRYLATE

本文报道了在GMA为206.0和15.3mg/m^3 下进行的家兔、大鼠慢性吸入毒性实验。结果表明:GMA的慢性毒作用广泛,以损害神经、心血管、血液系统和实质性脏器肝、肾为主。高浓度组家兔、大鼠绝大多数指标为阳性,心、肝、肾等有明显病理改变,在停止染毒1个月后,上述病理变化未见明显好转,且有渐进性增强的趋势,属不可逆性改变。低浓度组除少数指标呈阳性结果外,未见其它明显异常,虽也有心、肝、肾等轻度病理改变,但在停止染毒1个月后,基本恢复正常,属可逆性改变。由此认为,高浓度(206mg/m^3)为可引起机体产生明显反应的浓度,低浓度(15.3mg/m^3)为慢性阈浓度。

The chronic inhalation toxicity of glycidyl methacrylate (GMA) was tested on rabbits and rats with either a high (206mg/m3) and a low (15.3mg/ m3) concentration. A wide range of chronic toxic manifestations, such as lesion in central nervous system, cardiovascular system, blood system as well as liver and kidney,were seen.In the high concentration group. all the changes were more pronounced and, after the exposure of GMA was ceased, the pathological lesions only got worsened and therefore irreversible.In low concentration group, the changes were sparse and slight, and almost all vanished a month after the exposure was ended, suggesting their reversibility. It is considered that the high concentration (206mg/m3) could cause pathological changes and the low concentration (15.3mg/m3) might be the threshold concentration of intoxication on chronic exposure.