摘要
采用原子吸收光谱法对上海市区165名无职业铅接触史产妇的血铅、脐血铅、乳汁铅(119份)、胎盘组织铅(153份)样品进行测定,其均值分别为0.68±0.33μmol/L(14.13±16.79μg/dl)、0.40±0.23μmol/L(8.27±4.87μg/dl)、5.63±4.39ppb、1.14±1.10μmol/kg(23.73±22.85μg/100g)[中位数为0.63(13.2)、0.33(6.90)、4.74、0.86(17.85)]。产妇年龄对母血铅、脐血铅、乳汁铅和胎盘组织铅无显著影响。脐血铅、乳汁铅随母血铅增高而上升,其相关系数分别为0.714(P<0.0001)和0.353(P<0.01)。12名铅作业产妇平均年龄24岁,工龄1.9年,其乳汁铅几何均值为52.68ppb,显著高于非职业接触人群的4.43ppb(P<0.01),两者相差约12倍,提示对乳儿健康可能构成威胁。本文在国内首次报告了正常产妇的血铅、乳汁铅、脐血铅以及胎盘组织铅的参考值。
165 parturients in 2 hospitals in Shanghai were studied for lead levels in maternal blood, cord blood, breast milk and placental tissue, with the medians of them being 0.63μmol/L (13.2μg/dl) , 0.33μmol/L (6.90μg/dl) , 4.74ppb and 0.86 μmol/kg (17.85μg/100g) respectively. No significant difference was found between maternal age groups for these indicators. Lead levels in cord blood, breast milk increased with the lead level in maternal blood, and the correlation coefficients between them were 0.714 (p<0.001) and 0.353 (p< 0.01) respectively.Geometric mean of lead level in breast milk for 12 occupationally lead exposed women was 52.7 ppb, almost 12 times of that in non-occupationally lead exposed population.These results suggested that transfer of lead via placenta and milk might pose a potential risk prenatally or postnatally to fetus or neonates when the maternal blood lead level increased.
出处
《工业卫生与职业病》
CAS
CSCD
1990年第4期207-210,共4页
Industrial Health and Occupational Diseases
基金
国家教委会博士点基金
关键词
母血铅
脐血铅
乳汁铅
铅中毒
Lead level
maternal blood
cord blood
placental tissue
