通降和胃方治疗胃食管反流病合并夜间呛咳38例临床观察

Clinical Observation of "Tongjiang Hewei Decoction" in Treating 38 Cases of Gastroesophageal Reflux Disease with Nighttime Cough

目的观察通降和胃方治疗胃食管反流病(GERD)合并夜间呛咳的临床疗效。方法对38例患者采用通降和胃方治疗,观察治疗前后患者临床症状积分、胃镜下食管炎症改善情况,并随访复发率。结果①治疗前后患者临床症状积分、呛咳类呼吸道症状积分、胃食管反流症状积分均有显著差异(P<0.01);②临床症状改善总显效率为86.84%,呛咳类呼吸道症状改善显效率为86.84%,胃食管反流症状改善显效率为78.95%,三类症状改善显效率相比无统计学差异(P>0.05);③治疗后胃镜下食管炎症改善总有效率为73.68%;④停药2个月后呼吸道症状复发率为24.32%,胃食管反流症状复发率为37.83%。结论通降和胃方治疗胃食管反流病合并夜间呛咳,可有效缓解临床症状,减轻食管黏膜炎症,且具有复发率较低的优点。

Objective To observe the clinical effects of ＂Tongjiang Hewei Decoction＂ in the treatment of patients with gastroesophageal reflux disease（GERD） with nighttime cough. Method Thirty-eight cases were treated with ＂Tongjiang Hewei Decoction＂. The symptomatic scores and endoscopic results and recurrence rate were observed. Results The clinical symptomatic scores were obviously decreased after treatment （P 〈 0.01）; the effective rate for symptom improvement was 86.64%, the effective rate for nighttime cough improvement was 86.84%, the effective rate for reflux improvement was 78.95%. There was no statistical difference between the three（P〉 0.05）. The endoscopic results showed that the effective rate was 73.68%. The recurrence rate of nighttime cough was 24.32%, it was 37.83% for gastroesophageal reflux. Conclu- sion ＂Tongjiang Hewei Decoction＂ can relieve GERD with nighttime cough, improve clinical symptoms effectively, reduce the inflammation of esophageal mucosa and decrease recurrence rate.