原发性癫痫患者外周血活性T淋巴细胞亚群的研究

Determination of acivated T-Lymphocyte subsets of peripheral blood in the patients with idiopathic epilepsy Li Chaowu, Ruan Xuzhong, Sheng Guanxin

采用荧光－花环双标记法检测了４０例未服用抗癫痫药物原发性癫痫患者和３２例健康对照者外周血淋巴细胞同时表达ＤＲ抗原和ＣＤ抗原双标记活性Ｔ淋巴细胞亚群的分布，结果表明：原发性癫痫患者外周血淋巴细胞表达双抗原的ＤＲ＋ＣＤ＋３细胞和ＤＲ＋ＣＤ＋４细胞百分率均明显增高、ＤＲ＋ＣＤ＋８细胞百分率无明显改变，从而ＤＲ＋ＣＤ＋４／ＤＲ＋ＣＤ＋８细胞比值增高，且ＤＲ＋ＣＤ＋４细胞占相应亚群的百分率增高。提示：原发性癫痫患者存在免疫功能紊乱。

Using fluorescence rosette double labelling technigue, the author investigated T lymphocyte subsets of peripheral blood from 40 patiens with idiopathic epilepsy without taking any anticonvulsants and compared with those of 32 healthy controls. The result indicated that the percentages of double labelling DR + CD + 3 and DR + CD + 4 T lymphocytes and the ratio of DR + CD + 4/DR + CD + 8 were markedly elevated in the patients between the two groups. It was suggested that a disturbance of activated T Lymphocyte subsets and a highly activated T helper cell state were present in the patients with idiopathie epilepsy, which maight play a role in the immunopathogenic mechanism of epilepsy.