正丁基缩水甘油醚、环氧树脂6101~#的肝脏毒性及其联合毒性的实验研究

THE EXPERIMENTAL STUDY OF THE LIVER TOXICITY OF n-BUTYL GLYCIDYL ETHER (n-BGE,501) AND EPOXY RESIN 6101 AND THEIR JOINT ACTIONS

本文着重研究了正丁基缩水甘油醚(501~#)、环氧树脂6101~#的肝脏毒性。体外试验结果表明:501~#可使大鼠肝匀浆GSH含量降低、脂质过氧化增加,但对细胞色素P450无明显影响。6101~#可使细胞色素P450含量降低,但对脂质过氧化无明显影响。大鼠亚急性毒性试验结果表明:501~#对血滤波GSH、GSSG、GPT、血糖、肝脏GSH、GSSG、细胞色素P450均无明显影响。肝脏指数增大,但病理学检查无异常发现。501~#与6101~#联用在体外对肝匀浆脂质过氧化呈相加作用,但在体内对大鼠肝脏细胞色素P450无联合作用。结论认为:501~#、6101~#在一般接触情况下,不会引起明显的肝脏毒性。

Data reported here focusing on the liver toxicity of the compounds,n-BGE (501#) and epoxy resin (6101#) indicate that 501# may induce a decrease in the concentration of GSH and an increase in lipoperoxydation in the liver homogenate of the rats in vitro, but there is no apparent effect on the level of cytochrome P450. On the other hand, 6101# may induce decrease of the level of cytochrome P450, but has no effect on lipoperoxydation. The results of the subacute toxicity test of the rats show that 501# has effects on neither the concentration of GSH、GSSG、GPT and sugar of the blood, nor the concentration of GSH、 GSSG and cytochrome P450 of the liver. The liver index of the rats increases,but no abnormal change of the liver is observed The joint action of 501# and 6101# shows that there is an additive action in lipoperoxydation in homogenate of the liver in vitro, but they have no combined effect on the level of cytochrome P450 of liver in vivo. The results described above suggested that in general exposure condition,501# and 6101# have no apparent hazard to the liver.