原发性高血压患者代谢综合征发病情况的调查与分析

Investigation and analysis of the incidence of metabolic syndrome in patients with essential hypertension

目的调查原发性高血压患者代谢综合征(MS)的发病情况并分析其特点。方法选择原发性高血压患者843例,依据是否合并MS将患者分为MS组(494例)和非MS组(349例)。结果MS组与非MS组比较,年龄、体重指数、腰围、腰臀比、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、空腹血糖、血尿酸有显著性差异;在MS各单组分中,腹型肥胖的发生率最高(71.2%),女性腹型肥胖发生率显著高于男性(75.9%vs66.5%,P=0.003);原发性高血压患者MS发生率随年龄增长而增加,55岁以前,男性MS发生率高于女性,但差异无显著性意义(P>0.05),55岁以后,女性MS发生率显著高于男性(P<0.05)。结论MS的发生率在原发性高血压人群中显著高于正常人群,应高度重视原发性高血压患者,尤其是女性MS及腹型肥胖的预防和控制。

Objectives To investigate the incidence of metabolic syndrome（MS） in patients with essential hypertensive（EH） and to analyze its characteristics. Methods A cross-sectional survey was conducted in 843 patients with EH. The patients were divided into MS group（494） and non MS group（349） based on whether they were complicated with MS. Results Age, body mass index（BMI）, waist circumference（WC）, waist-to-hip ratio（WHR）, total cholesterol（TC）, highdensity lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol（LDL-C）, triglycerides（TG）, fasting plasma glucose（FPG） and serum uric acid（UA） were significantly different between MS group and non MS group. Among the components of MS,the incidence rate of abdominal obesity was the highest （71. 2%） and it was significantly higher in females than in males （75.9% vs 66.5 %, P =0. 003）. The incidence of MS in patients with EH was increased with age. Before 55 years old,the incidence of MS was higher in males than in females, but there was no significant difference （ P 〉0.05）. After 55 years old,the incidence of MS was significantly higher in females than in males （ P 〈0.05）. Conclusion Incidence of MS in patients with EH was significantly higher than that in healthy persons. Much attention should be paid to prevention and control of MS in patients with EH, especially in females.