伽玛刀治疗高危前列腺增生症的临床应用

The clinical reseach on treatment of high risk benign prostaric hyperplasia by Gamma knife

目的探讨伽玛刀在不适合开放手术或经尿道电切术的高危前列腺增生患者治疗中的应用。方法采用深圳奥沃公司生产的OUR-QGD型立体定向全身伽玛刀治疗20例高危前列腺增生患者。应用国际前列腺症状评分(IPSS)、前列腺重量、最大尿流率(Qmax)、残余尿量作为评价指标。观察上述数据在治疗前后的改变及其临床意义。结果术后随访6个月,IPSS评分由治疗前29分降至19.6分(P<0.01)。前列腺重量平均值均由治疗前的(56.4±4.4)g减少至(54.8±4.3)g(P>0.05)。最大尿流率平均值由治疗前的(6.7±1.8)ml/s增加至(11.5±1.7)ml/s(P<0.01),残余尿量平均值由治疗前的(85.1±27.8)ml降至(50.9±15.6)ml(P<0.01)。结论立体定位体部伽玛刀治疗高危前列腺增生症患者具有简便、安全、无创、痛苦小、并发症少、疗效好,可不需住院等优点,对不愿意接受手术或不宜手术的高危前列腺增生患者不失为一种良好的治疗方法,但费用较高。

Objective To study the clinical application of Gamma Knife for the treatment of high risk benign prostatic hyperplasia（BPH）. Methods 20 High risk BPH patients received the treatment with the OUR-QGD Gamma Knife （Made in Shenzhen AoWo company）. IPSS, prostatic weight,peak flow rate（Qmax）,residual urine volume was used for the,evaluation, Results After an average of 6 months follow-up,IPSS decreased significantly from 29 to 19.6 （P〈0.01）;peak flow rate（Qmax）increased from（6.7±1.8）ml/s to （11.5±1.7）ml/s （P〈0.01）.Residual urine volume decreased from （85.5±27.8）ml to（50.9±15.6）ml（P〈0.01）. Conclusion Gamma Knife for the treatment of high risk BPH is a simple,safe,uninvasive method with minimally pain,less complication,durability of clinical efficiency and needless hospitalization.It is a good treatment method for those patients that are not suitable for surgical management.