体感诱发电位、数量化脑电图与异氟醚吸入浓度的关系

Relationship of SEP,QEEG and isoflurane MAC during inhalation anesthesia

目的探讨短潜伏期体感诱发电位和数量化脑电图监测异氟醚吸入麻醉深度的可行性。方法选择全麻患者30例,麻醉诱导后吸入异氟醚,依次增加呼气末异氟醚浓度为0.4、0.7、1.0、1.3和1.6MAC,记录麻醉过程中MAP、HR、数量化脑电图(BIS、95%SEF和MF)和体感诱发电位(LP15、LN20、LN11和CCT),计算各监测指标与异氟醚吸入浓度的相关性。结果患者HR、LN11与呼气末异氟醚浓度变化无直线相关关系;MAP、BIS、95%SEF和MF与呼气末异氟醚浓度变化呈负相关关系(P<0.05),而LP15、LN20和CCT与呼气末异氟醚浓度变化呈正相关关系(P<0.05)。结论BIS、95%SEF、MF、LN20和CCT是监测异氟醚吸入麻醉深度的较好指标。

Objective To investigate the relationship of short latency somatosensory evoked potentials（SEP） and quantitative electroencephalogram （QEEG）,with isoflurane concentration during inhalation anesthesia. Methods Thirty patients undergoing general anesthesia were studied. The mean arterial blood pressure（MAP）, heart rate（ H R）, QEEG（BIS, 9 5% SEF, MF） and SEP（Lp15, LN20, LN1,, CCT） were recorded at end-tidal concentration of isoflurane 0.4,0.7,1.0 and 1.3 MAC,respectively. The correlation among them was calculated. Results Alteration of HR and LN11 was not correlated to end-tidal concentration of isoflurane. There was a negative correlation between MAP, BIS, 95% SEF or MF and end-tidal concentration （P 〈 0. 05）. There was a positive correlativen between Lp15, LN20 or CCT and end-tidal concentration（P〈0.05）. Conclusion The BIS, 95%SEF,MF,LN20 and CCT are the sensitive indicators for monitoring the depth of isoflurane anesthesia.