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慢性肾功能衰竭血管钙化的研究进展 被引量：1

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摘要 　　终末期肾功能衰竭患者的病死率远高于与之年龄匹配的普通人群,由于心血管事件造成的死亡占总死亡原因的50%以上.一些非传统的尿毒症及与透析相关的危险因素如贫血、营养不良、高磷血症及高钙磷乘积等,现已被证实参与了心血管疾病（CVD）的发生及发展.其中钙磷代谢紊乱及与之相关的血管钙化发生率增加受到了广泛关注,血管钙化与粥样硬化斑块数量、心肌梗死和心脏骤停等心血管事件均密切相关.现就慢性肾功能衰竭血管钙化的研究进展作一综述.
作者 张敏芳 钱家麒
机构地区 上海交通大学医学院附属仁济医院肾内科
出处 《上海医学》 CAS CSCD 北大核心 2007年第7期553-556,共4页 Shanghai Medical Journal
关键词 慢性肾功能衰竭 血管钙化 肾功能衰竭患者 心血管事件 钙磷代谢紊乱 粥样硬化斑块 心血管疾病 普通人群
分类号 R692.5 [医药卫生—泌尿科学]
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参考文献27

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同被引文献18

  • 1黄颂敏,柳飞.慢性肾脏疾病与血管钙化[J].中国中西医结合肾病杂志,2006,7(4):187-191. 被引量：1
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  • 3Lomashvili KA,Garg P,Narisawa S.Upregulation of alkaline phosphatase and pyrophosphate hydrolysis:Potential mechanism for uremic vascular calcification. Kidney International . 2008
  • 4Mizobuchi M,Towler D,Slatopolsky E.Vascular calcification:the killer of patients with chronic kidney disease. Journal of the American Society of Nephrology . 2009
  • 5Moe SM,Chen NX.Mechanisms of vascular calcification in chronic kidney disease. Journal of the American Society of Nephrology . 2008
  • 6Price P A,Caputo J M,Williamson M.Bone origin of the serumcomplex of calcium,phosphate,fetuin,and matrix Gla protein:biochemical evidence for the cancellous bone-remodeling com-part ment. Journal of Bone and Mineral Research . 2002
  • 7Cecillia M Giachelli.Vascular calcification mechanisms. Journal of American Society of Nephrology . 2004
  • 8El-Abbadi M,Giachelli CM.Mechanisms of vascular calcification. Adv Chronic Kidney Dis . 2007
  • 9Abedin M,Tintut Y,Demer LL.Vascular calcification: mechanisms and clinical ramifications. Arteriosclerosis . 2004
  • 10Luo G,Ducy P,McKee MD,et al.Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature . 1997

引证文献1

上海医学
2007年 第7期

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