MIC-1、VEGF和P53蛋白表达与直肠癌临床病理及预后的关系

Expression of MIC-1,VEGF and p53 in rectal cancer and their clinicopathological significances

背景与目的:巨噬细胞是重要的免疫效应细胞,对肿瘤的发生、发展发挥着重要的调控作用。本研究探讨巨噬细胞抑制细胞因子-1(MIC-1)、血管内皮生长因子(VEGF)、P53蛋白的表达与直肠癌临床病理特征及预后的相关性。方法:用免疫组化法检测73例直肠癌中MIC-1、VEGF和P53的表达,并与临床病理因素及预后进行相关性分析。结果:MIC-1表达与VEGF、P53表达呈正相关(P<0.05);MIC-1、VEGF和P53表达与直肠癌肿瘤临床分期、淋巴结转移呈明显相关性(P<0.01);MIC-1和VEGF、P53阳性组和阴性组的5年生存率差异均有显著性(P<0.01)。结论:MIC-1、VEGF和P53与直肠癌淋巴结转移、分期及预后有密切关系,淋巴结转移是最重要的独立的预后因素。

Background and purpose： Macrophage is an important immune effector cell and plays a key role in modulation and development of tumorigenesis. We investigated the expressions of Maerophage inhibitory eytokine-1 （MIC-1）, VEGF and P53 in rectal cancers, and their relation with eliniealpathologieal parameters and prognosis. Methods： The expressions of MIC-1, VEGF and P53 in 73 cases of rectal cancer were assessed by immunohistochemistry, and their correlation with elinieopathological factors and prognosis were analyzed. Results： The expression of MIC-1 had a positive correlation with the expressions of VEGF and P53（ P 〈 0. 05）, The expressions of MIC-1, VEGF and P53 had significant correlation with clinical stage and nodal metastasis. The expression of MIC-1, P53 and VEGF had a significant correlation with prognosis in rectal cancer（ P 〈0.01）. Conclusions： The expression of MIC-1, P53 and VEGF in rectal cancer may be related to tumor development, tumorigenesis and prognosis. Nodal metastasis was the most important available independent prognostic factor in rectal cancer.