摘要
背景与目的:巨噬细胞是重要的免疫效应细胞,对肿瘤的发生、发展发挥着重要的调控作用。本研究探讨巨噬细胞抑制细胞因子-1(MIC-1)、血管内皮生长因子(VEGF)、P53蛋白的表达与直肠癌临床病理特征及预后的相关性。方法:用免疫组化法检测73例直肠癌中MIC-1、VEGF和P53的表达,并与临床病理因素及预后进行相关性分析。结果:MIC-1表达与VEGF、P53表达呈正相关(P<0.05);MIC-1、VEGF和P53表达与直肠癌肿瘤临床分期、淋巴结转移呈明显相关性(P<0.01);MIC-1和VEGF、P53阳性组和阴性组的5年生存率差异均有显著性(P<0.01)。结论:MIC-1、VEGF和P53与直肠癌淋巴结转移、分期及预后有密切关系,淋巴结转移是最重要的独立的预后因素。
Background and purpose: Macrophage is an important immune effector cell and plays a key role in modulation and development of tumorigenesis. We investigated the expressions of Maerophage inhibitory eytokine-1 (MIC-1), VEGF and P53 in rectal cancers, and their relation with eliniealpathologieal parameters and prognosis. Methods: The expressions of MIC-1, VEGF and P53 in 73 cases of rectal cancer were assessed by immunohistochemistry, and their correlation with elinieopathological factors and prognosis were analyzed. Results: The expression of MIC-1 had a positive correlation with the expressions of VEGF and P53( P 〈 0. 05), The expressions of MIC-1, VEGF and P53 had significant correlation with clinical stage and nodal metastasis. The expression of MIC-1, P53 and VEGF had a significant correlation with prognosis in rectal cancer( P 〈0.01). Conclusions: The expression of MIC-1, P53 and VEGF in rectal cancer may be related to tumor development, tumorigenesis and prognosis. Nodal metastasis was the most important available independent prognostic factor in rectal cancer.
出处
《中国癌症杂志》
CAS
CSCD
2007年第8期607-609,共3页
China Oncology
关键词
直肠癌
MIC-1
VEGF
P53
rectal cancer
macrophage inhibitory cytokine-1
VEGF
P53