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大肠癌组织中EphA2,VEGF和MMP9蛋白的表达及其相关性研究 被引量：4

The correlation and expression of EphA2 ,VEGF and MMP9 proteins in human colorectal carcinoma
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摘要 为探讨大肠癌组织中EphA2,VEGF和MMP9蛋白的表达及其与大肠癌生物学行为的关系。笔者应用免疫组织化学S-P法检测69例大肠癌组织及30例远癌肠黏膜中EphA2,VEGF,MMP9蛋白的表达。结果示,大肠癌组织中EphA2蛋白(100%)表达显著高于远癌肠黏膜(80.0%)(P<0.01),且与Dukes分期、肿瘤组织分化程度及肉眼类型有关(P<0.05),而与年龄无关(P>0.05)。VEGF蛋白及MMP9蛋白在大肠癌中的表达均显著高于远癌肠黏膜(均P<0.01),与Dukes分期有关(P<0.05),但与年龄、肿瘤组织分化程度及肉眼类型等无关(均P>0.05)。EphA2蛋白在大肠癌中的表达与VEGF,MMP9呈正相关(r1=0.404,P1=0.000;r2=0.282,P2=0.000)。提示联合检测EphA2,VEGF和MMP9有助于对大肠癌侵袭及转移能力的评估,对大肠癌的预后判断可能具有一定的临床意义。
作者 蒋萍 李景和 罗庚求 沈明 刘洁 李红玲
机构地区 中南大学基础医学院病理学系
出处 《中国普通外科杂志》 CAS CSCD 2007年第7期696-699,共4页 China Journal of General Surgery
关键词 结直肠肿瘤/病理学 EPHA2 VEGF MMP9
分类号 R735.1 [医药卫生—肿瘤]
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参考文献8

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同被引文献30

  • 1冯延平,黄涛,高军,常青,秦仁义.EphA2与E-cadherin在胰腺癌中的表达及其意义[J].中国普通外科杂志,2005,14(12):914-917. 被引量：8
  • 2吴泽宇,罗中仁,万进,杜嘉林.中下段直肠癌E-cadherin,MMP-2和VEGF表达与肿瘤侵袭转移的关系[J].中国普通外科杂志,2007,16(4):387-389. 被引量：13
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引证文献4

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中国普通外科杂志
2007年 第7期

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