摘要
目的:分析垂体肿瘤转化基因(pituitary tumor-transforming gene,PTTG)和转化生长因子β1(transforming growth factor β1,TGF-β1)及受体(TGF-RⅡ)在肝癌组织中的表达及三者之间的关系。方法:应用免疫组化SP法检测原发肝细胞性肝癌(hepato cellular carcinoma,HCC)组织50例、肝硬化组织30例、正常肝组织10例中PTTG、TGF-β1和TGF-RⅡ的表达。结果:PTTG在肝硬化组织中的表达高于肝癌组织的表达,差异有统计学意义,χ2=4.30,P<0.05。TGF-β1在肝癌和肝硬化组织中的表达差异无统计学意义,χ2=1.55,P>0.05。TGF-RⅡ在正常肝组织的表达高于肝癌肝硬化的表达,χ2=27.20,P<0.01;χ2=16.68,P<0.01。结论:PTTG、TGF-β1和TGF-RⅡ异常表达与肝癌、肝硬化的发展密切相关,为肝癌、肝硬化的治疗提供了较为客观的参考指标。
OBJECTIVE: To explore the relationship among the expressions of PTTG, TGF-β1 and TGF-R Ⅱ in hepatocellular carcinoma. METHODS: The expressions of PTTG, TGF-β1 and TGF-RⅡ in 50 cancer tissues, 30 cirrhosis tissues and 10 normal tissues were assessed by immunohistochemical method. RESULTS: The expression of PTTG in cirrhosis tissues was higher than that in cancer tissues, Χ^2 = 4.30, P〈0. 05. There was no statistics difference of the TGF-β1 expressions in cancer tissues and cirrhosis tissues, Χ^2 = 1.55, P〉 0. 05. The expressions of TGF-RⅡ in normal tissues was higher than that in cancer tissues and in cirrhosis tissues, Χ^2 = 27. 20, P〈0.01;Χ^2 = 16.68, P〈0.01. CONCLUSIONS: The abnormal expressions of PTTG, TGF-β1 and TGF-RⅡ are closely associated with the development of liver cancer and cirrhosis of liver. They can be used as indicators for the therapy in hepatocellular carcinoma and cirrhosis of liver.
出处
《中华肿瘤防治杂志》
CAS
2007年第16期1223-1225,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
受体
转化生长因子Β
肝肿瘤/病理学
肝硬化
癌基因
receptors, transforming growth factor beta
liver neoplasms/pathology
liver cirrhosis
oncogenes