脑胶质瘤放射敏感性基因研究的进展

The progress of radiosensitive genes of human brain gliomas

脑胶质瘤是颅内常见的恶性肿瘤之一。在脑胶质瘤的综合治疗方法中,放射治疗与手术治疗一样占有重要地位。脑胶质瘤对放射线的敏感程度直接影响放射治疗疗效。脑胶质瘤内在的放射敏感性基因及其引起的细胞凋亡、细胞周期的变化和放射线导致的DNA损伤修复等,都与脑胶质瘤的放射敏感性密切相关。与细胞凋亡相关基因和DNA修复相关基因相关的脑胶质瘤放射敏感性基因,正逐渐成为人们研究的热点,还有其他的一些脑胶质瘤放射敏感性基因也受到人们的关注。现就脑胶质瘤放射敏感性基因研究的现状和进展作一综述。

Human gliomas are one of the most aggressive tumors in brain. Radiotherapy plays an important role for patients with gliomas, as well as surgery. The efficacy of radiotherapy is associated with radiosensitivity of human gliomas. Radiosensitive genes of gliomas and apoptosis, cell cycle transformation,DNA damage induced by irradiation and DNA repair promoted by them are suggested to be associated with glioma radiosensitivity. The rediosensitive genes associated with apoptosis and DNA repairment are becoming hot spots of study. The other radiosensitivity genes are paid attention too. This paper makes a summary of current situation and progress for radiosensitive genes of human brain glomas.