血糖波动性的临床意义及其干预研究

Glucose fluctuation and intervention in its clinical significance

糖尿病慢性并发症的发生、发展不仅与整体血糖水平相关,而且与血糖波动性有密切关系。血糖大幅波动可能通过激发多种代谢途径而导致微血管和大血管损伤。临床造成糖尿病患者血糖波动过大的主要原因有两个:未经合理控制的餐后高血糖和治疗不当导致的低血糖。α-葡萄糖苷酶抑制剂、格列萘类胰岛素促泌剂及速效、长效人胰岛素类似物等新剂型的出现,使糖尿病的治疗更加精细和安全,血糖控制更加严格和平稳,为减少血糖波动提供了有力武器。

The initiation and development of diabetic chronic complications is associated not only with the level of blood glucose, but also with the glucose fluctuation. The damage in large artery and microvessel may be caused by glucose fluctuation. There are two causes which induce glucose fluctuation in clinical：one is postprandial hyperglyceamia with not well controlled, the other is hypoglycemia causes by unsuitable therapy. A lot of effective new types of substances were applicated in clinical, such as α- glucosidase inhibitor, glinide-insulin secretagogus, fast-acting and long-acting insulin analogues. With these new powerful tools, there is possibility to treat diabetes more correctly and safely, and control the blood glucose in a stable and good level.