新型广谱三唑类抗真菌药泊沙康唑

A novel broad-spectrum triazole antifungal,pasaconazole

泊沙康唑为一新型三唑类抗真菌药,用于治疗和预防侵袭性真菌感染。体内外试验表明,其具有广谱抗菌活性,对念珠菌属、新隐球菌属、曲霉菌属、接合菌属和地方真菌有效,并有良好的耐受性,不良反应轻微。现对其作用机制、药动学、临床评价及不良反应做一综述。

Posaconazale is a new triazole drug for the treatment and prevention of invasive fungal infections. In vitro and in vivo studies showed that posaconazole has broad-spectrum activity against most Candida species, Cryptococcus neoformans, Aspergillus species, Fusarium species, zygomycetes, and endemic fungi. Posaconazole is widely distributed in the body, metabolised mainly by the liver, and is well tolerated. Adverse events are generally mild and including headache and gastrointestinal complaints. This article reviewed the mechanism pharmacokintics,clinical evaluation and adverse events of posaconazole.