石榴籽中2个木脂素的分离与鉴定

Isolation and Determination on Two Lignans from the Seeds of Punica granatum

[目的]为了开发石榴籽的药用价值,分析研究其药用物质的化学成分。[方法]采用硅胶柱层析法从石榴籽中分离得到2个木脂素类化合物,通过结构解析和波谱数据确定其组成。[结果]化合物1为白色无定形粉末,易溶于氯仿,有20个碳,包括12个C,4个CH,2个CH2,2个CH3O,推出化合物分子式为C20H22O6,化合物骨架为二倍体双四氢呋喃类木质素。化合物2为白色无定形粉末,易溶于氯仿,有20个碳,包括7个C,8个CH,3个CH2,2个CH3O,可推出化合物分子式为C20H22O6,其确定为二芳基丁内脂型木脂素。[结论]确定2个化合物分别为连翘脂素和罗汉松脂素,均为首次从该种植物中分离得到。

[Objective] The study aimed to develop the medicinal value of Punica granatum seed and analyze the chemical component of its medicinal material. [Method] Two lignan compounds were isolated from Punica granatum seed by column chromatography with silica gel and their composition were confirmed based on structure analysis and spectrum data. [Result] The compound 1 was white power without amorphous state, easy to be dissolved in chloroform and had 20 carbon including 12 C, 4 CH, 2 CH2 and 2 CH3O, with the molecular formula as C20H22O6. Its compound framework was confirmed as diploid ditetrahydrofuran type lignin. The compound 2 was white power without amorphous state, easy to be dissolved in chloroform and had 20 carbon including 7 C, 8 CH, 3 CH2 and 2 CH3O, with the molecular formula as C20H22O6. Its compound framework was confirmed as diaryl group butyrolactone type lignan. [Conclusion] The two compounds were confirmed as phillygenin and matairesinol and both were isolated from the P. granatum first.