左氧氟沙星选择性电极的制备及其性能研究

Study on preparation and property of a levofloxacin selective electrode

以左氧氟沙星与四苯硼酸根形成的缔合物为电活性物质,研制了一种左氧氟沙星PVC膜涂层玻璃电极,并对其响应性能进行了系统研究。实验表明,该电极的Nernst响应范围为5.0×10-3～2.0×10-5moL/L,斜率为51.7mV/pC,适用pH范围为3.0～4.5。该电极制作方法简单,响应迅速,重现性好,用于左氧氟沙星注射液和片剂的测定。

The levofloxacin selective electrode prepared by coating the mixture of levofloxacin and sodium tetraphenylboron association complex with PVC membrane on a glass electrode is reported.The electrode gave Nernst response to levofloxacin over the concentration range of 5.0×10^-3～2.0×10^-5 moL/L with a slope of 51.7 mV/pC.The electrode showed a high selectivity and fast response.It has been used for the determination of levofloxacin in levofloxacin injections and tablets.The method is simple and the results are satisfactory.