肝硬变患者血清层粘连蛋白水平的变化

Serum laminin concentrations in patients with liver cirrhosis

目的：探讨肝硬变（ＬＣ）患者血清层粘连蛋白（ＬＭ）水平变化的影响因素及其临床意义．方法：应用放射免疫分析法测定６２例ＬＣ患者血清ＬＭ含量．结果：肝硬变患者血清ＬＭ［（１４８．７２±３６．５７）μｇ／Ｌ］，显著高于献血员对照组［（１０５．８１±１４．５６）μｇ／Ｌ，Ｐ＜０．０１］．Ｃｈｉｌｄ＇ｓＡ、Ｂ、Ｃ各级［（１２５．３５±３０．６２）μｇ／Ｌ，Ｐ＞０．０５；（１４５．６８±２７．９５）μｇ／Ｌ，Ｐ＜０．０１；（１７１．６５±４３．９９）μｇ／Ｌ，Ｐ＜０．０１］依次递增．ＬＣ患者血清ＬＭ与其血清胆红素、谷丙转氨酶含量有正相关性（ｒ＝０．３３９，ｒ＝０．２７２，Ｐ＜０．０１，Ｐ＜０．０５），与门静脉高压程度无明显相关（Ｐ＞０．０５）．结论：肝功能损害可能是肝硬变患者血清ＬＭ升高的重要原因．ＬＭ与门静脉高压无明显相关．

Objective: To study the serum concentration changes of laminin (LM) in liver cirrhosis and their clinical significance. Methods: Radioimmunoassay was applied to determine the serum levels of laminin in 62 patients with liver cirrhosis (LC). Result: Serum LM concentrations in LC patients [(148.72±36.57) μg/L] were markedly higher than those in controls [(105.81±14.56) μg/L, P <0.01]. Serum levels of LM in Child's A, B, C [(125.35±30.62) μg/L, P >0.05; (145.68±27.95) μg/L, P <0.01; (171.65±43.99) μg/L, P <0.01] increased class by class. LM contents were positively correlated with BIL and ALT levels in LC patients, but they had no significant association with portal hypertension ( P >0.05). Conclusion: Liver dysfunction seems to play an important part in the increase of serum LM, which were independent of portal hypertension.