氩激光诱发兔视网膜下新生血管的眼底荧光血管造影

Fundus fluorescein angiography study of subretinal neovascularization induced by argon laser in the rabbit

目的：探讨视网膜下新生血管（ＳＲＮＶ）的发病机理及发生、发展特点．方法：用高强度氩激光光凝兔视网膜，经眼底镜及眼底荧光血管造影（ＦＦＡ）观察．结果：光斑出血发生率为２７％．光凝后１周，ＦＦＡ脉络膜期及动脉早期８％的光斑有点状荧光素渗漏．光凝后３周，６３％的光斑出现脉络膜新生血管（ＣＮＶ）形态．直至２个月，渗漏区逐渐扩大．光凝后３～４个月时，渗漏范围渐缩小．结论：ＣＮＶ的发生时间为１周．兔眼的ＳＲＮＶ发生率较高（６３％），是研究ＳＲＮＶ的理想模型．其发展过程可分为活动期及退化期，时间各为８～１０周左右．

Objective: The purpose was to study the pathogenesis and the characteristics of the development and occurrence of the subretinal neovascularization (SRNV). Methods: The rabbit's retinal was photocoagulated with high energy argon laser and was observed with funduscope and fundus fluorescein angiography (FFA). Results: The result showed a 27% incidence of laser burns hemorrhage. One week after photocoagulation, there was dot shaped fluorescein leakage on 8% of the spots at early arterial phase and choroidal phase. Three weeks after photocoagulation, the shape of choroidal neovascularization (CNV) appeared on 63% of the spots. The leakage area expanded until two months later. Three to four months after photocoagulation, the leakage area shrank gradually. Conclusion: The time of generation of SRNV is about one week. Rabbit's eyes are ideal models for the study of SRNV as the rate of occurrence of neovascularization is quite high. The process of its development can be divided into the active stage and the degeneration stage, with eight to ten weeks for each stage.