直肠癌患者手术治疗前后血清IGF-I、CEA和TSGF检测的临床意义

Clinical Significance of Changes of Serum Levels of IGF-I,CEA and TSGF After Operation in Patients with Rectal Cancer

目的:探讨了直肠癌患者手术治疗前后的血清IGF-I、CEA和TSGF水平的变化及临床意义。方法:分别应用放免法和化学法对36例直肠癌患者进行了血清IGF-I、CEA和TSGF水平的检测,并与35名正常健康人作比较。结果:手术前直肠癌患者血清IGF-I、CEA和TSGF水平非常显著地高于正常人(P<0.01),手术治疗一年后复发组明显地高于未复发组(P<0.01)。结论:检测直肠癌患者血清IGF-I、CEA和TS-GF水平的变化与直肠癌患者的病情和预后密切相关,具有重要的临床价值。

Objective To study the clinical significance of changes of serum levels of IGF - I, CEA and TSGF after operation in patients with rectal cancer. Methods Serum IGF - I, CEA （with RIA）, and TSGF （with chemistry method） levels were detected in 36 patients with rectal cancer and 35 controls. Results Serum levels of IGF - I, CEA and TSGF in patients with rectal cancer before opcratlon were significantly higher than those in controls （ P 〈 0.01 ）. Postoperatively twenty - eight of 33 patients had no recurrence at I year and their serum IGF - I, CEA and TSGF dropped to within normal range. However, these serum markers in 5 patients with recurrence remained al）normally high （ vs levels in patients without recurrence, P 〈 0. 01 ）. Conclusion Serum IGF - I, CEA and TS- GF levels were closely related to the diseases process of rectal cancer and were of prognostic values.