大蒜素对白色念珠菌生长的抑制作用

Inhibition of Allicin against Candida albicans in vitro

探讨大蒜素对白色念珠菌生长的抑制作用。以NCCLS方案检测了胡桃楸提取物和伊曲康唑(ICZ)、氟康唑(FCZ)、两性霉素B(AMB)和5-氟胞嘧啶(5-FC)对133株白念珠菌体外生长抑制作用。标准菌株JC1A的M IC结果表明大蒜素提取物对白念珠菌的抗菌作用相当于FCZ,略低于ICZ、AMB和5-FC;临床分离株对ICZ和FCZ的耐药率很高,对大蒜素提取物的耐药率较低。大蒜素提取物对白色念珠菌生长有强力抑制作用。

Inhibition of allicin against Candida albicans in vitro was investigated.First inhibition of Manchurian walnut（Junglans mandchuricum） extract,ICZ,FCZ AMB,and 5-FC against 133 strains of C.albicans in vitro were tested with NCCLS work programme.The MIC results of JC1A standard strain indicated that the inhibition of allicin against C.albicans was equivalent to FCZ,slightly lower than ICZ,AMB,and 5-FC.The resistance rate of ICZ and FCZ against clinically isolated strain of C.albicans was very high,while of allicin was fairly low.Allicin has strong inhibition against the growth of C.albicans.