中年人群代谢综合征及其组分与心电图QT间期关系研究

Study on the relationship between QT interval and metabolic syndrome in adult Chinese population

目的探讨中年人群代谢综合征（metabolic syndrome,MS）及其组分与心电图QT间期的关系。方法2003—2006年对975名“宫内发育与成人疾病”队列人群（1948—1954年在北京协和医院出生的活产单子,其中男494名,女481名,年龄41～53岁）进行流行病学调查、身体测量、血生化指标测定及MS诊断,记录标准12导联心电图,用Bazett公式计算校正的QT间期（QTc）。采用稳态模式评估法计算胰岛素抵抗指数（HOMA-IR）。结果该中年人群心电图QT间期延长者262例（占26.9%）,MS、HOMA-IR、中心性肥胖、高血压、高血糖、高三酰甘油（TG）、低高密度脂蛋白胆固醇（HDL-C）的检出率分别为19.7%,19.5%,42.5%,34.3%,26.3%,34.6%,31.1%。心电图QT间期延长与中心性肥胖、高血糖、高TG、胰岛素抵抗（IR）、MS及异常组分聚集有相关关系（P〈0.05）。结论心电图QT间期延长与多项代谢异常组分、代谢异常聚集及代谢综合征有相关联系。

Objective To study the relationship between QT interval and the components of metabolic syndrome in aduh Chinese population. Methods Totally 975 aduhs（494 men and 481 women）aged 41～53 from the study cohort of Fetal Origin of Adult Disease（FOAD） were recruited in the study for epidemiologic examinations,involving anthropometry and measurements of blood pressure, fasting and 2hr plasma levels of glucose and insulin and serum levels of lipid. A standard 12-lead ECG was recorded and the Corrected QT（QTc） was calculated accordingly by Bazett formula. HOMA-IR index was calculated for estimating individual insulin resistance. Metabolic syndrome（MS） was diagnosed according to the definition issued by the International Diabetes Federation（IDF） in 2005. Results The prolonged QT interval was found in 262 of the 975 eases（26. 9% ） ,and the rates of prolonged QT interval being 21.6% and 32. 6% in men and women respectively （ P = 0. 0001 ）. The prevalences of MS, IR, central obesity, IFG, higher serum level of triglyceride （ TG ） and lower serum level of high-density lipoprotein cholesterol（HDL-C） were 19. 7%, 19. 5% ,42. 5% ,34. 3% ,26. 3% ,34. 6% and 31.1% in this mid-aged population respectively. The prolonged QT interval was significantly associated with MS, IR, IFG, higher serum level of triglyceride （TG）and certral obesity respectively （P 〈 0. 05 ）. Conclusion The prolonged QT interval was significantly correlated with MS and components of abnormal metabolism.