围绝经期妇女糖耐量低减与颈动脉病变的相关性研究

A Study of Relativity Between Carotid Atherosclerosis and Impaired Glucose Tolerance in Pri-menopausal Women

目的:探讨围绝经期妇女糖耐量低减与颈动脉粥样硬化及内中膜厚度的关系。方法:选择体检中发现的围绝经期伴糖耐量低减(IGT)者86例作为病例组,另选同期进行体检的围绝经期糖耐量正常(NGT)者92例作为对照组,全部病例均填写体检表及调查问卷,进行常规体检并检测空腹血糖、血脂及口服葡萄糖耐量试验;利用二维彩色多普勒超声显像仪检测颈动脉内中膜厚度,并观察颈动脉粥样硬化斑块的发生情况。分析IGT与血压、血脂及体重指数的关系。结果:IGT组颈动脉内—中膜厚度及粥样斑块检出率显著高于对照组,血压、血脂及体重指数亦高于对照组,两组比较差异显著,P<0.05。结论:颈动脉内中膜增厚及粥样硬化斑块在围绝经期伴糖耐量低减者中有较高的发生率,早期动脉粥样硬化改变早在糖耐量低减阶段就已经开始。

Objective： To investigate the relationship between impaired glucose tolerance （IGT）and carotid atherosclerosis, the intimal medial thickness （IMT） in pri-menopausal women. Methods： 86 cases of pri-menopausal women with imparied glucose tolerance were chosen in healthy examination as test group. And another 92 cases of pri-menopausal women with normal glucose tolerance （N6T） were synchronization chose as contrast group. All of cases to fill in health examination tab as well as Invest questionnaire. The health examination, fasting glucose, lipid, 2-hour 06TT were taken for examination Using 2D color Doppler ultrasonic angiograph test the intimal media] thickness and observing the development of atheromatous plaque. Then analysing the blood pressure, BMI and the lever of lipids relationship with IGT. Results： In IGT groups the test ratio of the intimal medial thickness and development of atheromatous plaque is patency higher than control group, the blood pressure, lipid, and BMI is also higter thatn them. （P〈 0. 05）. Condusion： The rate of scleratheroma of carotid and the intimal medial thickness is high in vi-menopausal women with impaired glucose tolerance. Ealier period change of carotid atherosclerosis is already initiate in impaired glucose tolerance stage.