田基黄抗痛风的实验研究

Hypericum japonicum Thunb. in the Treatment of Gout:An Empirical Study

目的:研究田基黄抗痛风的作用。方法:观察田基黄提取物对尿酸(MSU)所致大鼠足爪肿胀的影响;对MSU诱导家兔急性关节炎的影响;对次黄嘌呤所致小鼠高尿酸血症的影响;对小鼠扭体反应的影响及小鼠耳廓肿胀法观察田基提取物品抗炎、镇痛作用。结果:田基黄对MSU所致大鼠足爪肿胀有较好的抑制作用,能减轻MSU所致家兔急性关节炎炎症,降低高尿酸血症模型小鼠血尿酸值,有一定的抗炎作用,但镇痛作用较弱。结论:田基黄具有抗痛风作用,值得进一步研究开发。

OBJECTIVE： To observe the therapeutic effects of Hypericurn japonicurn Thunb. on gout. METHODS： The anti-gout, anti-inflammatory, and analgesic effects of Hypericurn japonicurn Thunb. extract were studied by observing its effects on rat＇s foot swelling induced by MSU, rabbit＇ s acute gouty arthritis model stimulated by MSU, the level of blood uric acid in hyperuricacidemia model, swelling of auricle, and writhing response of rabbits. RESULTS： Hypericurn japonicurn Thunb. could satisfactory inhibit acute gouty arthritis, relieve rat＇s foot swelling, reduce the blood uric acid （BUA） in model rabbits and it has anti-inflammatory effect to some degree its analgesic effect was not so obvious. CONCLUSION：Hypericurn japonicurn Thunb. was proved to be of therapeutic effect on gout, further research and development of which remains to be done.