摘要
目的:研究田基黄抗痛风的作用。方法:观察田基黄提取物对尿酸(MSU)所致大鼠足爪肿胀的影响;对MSU诱导家兔急性关节炎的影响;对次黄嘌呤所致小鼠高尿酸血症的影响;对小鼠扭体反应的影响及小鼠耳廓肿胀法观察田基提取物品抗炎、镇痛作用。结果:田基黄对MSU所致大鼠足爪肿胀有较好的抑制作用,能减轻MSU所致家兔急性关节炎炎症,降低高尿酸血症模型小鼠血尿酸值,有一定的抗炎作用,但镇痛作用较弱。结论:田基黄具有抗痛风作用,值得进一步研究开发。
OBJECTIVE: To observe the therapeutic effects of Hypericurn japonicurn Thunb. on gout. METHODS: The anti-gout, anti-inflammatory, and analgesic effects of Hypericurn japonicurn Thunb. extract were studied by observing its effects on rat's foot swelling induced by MSU, rabbit' s acute gouty arthritis model stimulated by MSU, the level of blood uric acid in hyperuricacidemia model, swelling of auricle, and writhing response of rabbits. RESULTS: Hypericurn japonicurn Thunb. could satisfactory inhibit acute gouty arthritis, relieve rat's foot swelling, reduce the blood uric acid (BUA) in model rabbits and it has anti-inflammatory effect to some degree its analgesic effect was not so obvious. CONCLUSION:Hypericurn japonicurn Thunb. was proved to be of therapeutic effect on gout, further research and development of which remains to be done.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第24期1858-1861,共4页
China Pharmacy
关键词
田基黄
痛风
实验研究
Hypericum japonicum Thunb.
Gout
Empirical study