蒽环类药物对白血病细胞的细胞毒作用与活性氧的关系研究进展

Recent advances of reactive oxygen species and cytotoxicity of anthracycline on leukemia cells

蒽环类抗生素用于白血病的治疗已30余年历史,已成为化疗不可缺少的药物之一。近年来研究显示,蒽环类抗生素对白血病细胞的细胞毒作用包括凋亡。而活性氧(reactive oxygen species,ROS)是细胞增殖、分化、成熟及凋亡过程中的重要介质;同时它与细胞耐药、心脏毒性有关。研究其作用机制将更好地了解白血病化疗的机制,更好地指导临床治疗。文章简述了蒽环类药物的作用机制及ROS与蒽环类药物细胞毒作用的关系,以期为临床研究提供参考。

Anthracycline has been used to treat leukemia for over thirty years. It has become one of the most essential drugs of chemotherapeutics. For the past a few years, researches have shown that reactive oxygen species （ROS） are generated, when anthracyeline antibiotics act on leukemia cells, as important mediator of cells proliferation, differentiation, maturation and apoptosis. It also relates with drug resistance and heart toxicity. Study on anthracycline antibiotics is useful to know more about its chemotherapy mechanism and to guide treatment. The advances of ROS and cytotoxicity of anthracycline antibiotics on leukemia cells is reviewed.