外周血PGI_2和T细胞亚群水平与生殖器疱疹复发频率相关性分析

Analysis of Relationship among GH Recurrence Frequence,Peripheral Blood PGI_2 and T Lymphocyte Subtype

目的探讨生殖器疱疹(GH)患者外周血PGI2水平及CD4+/CD8+T淋巴细胞比值及患者行为因素与GH复发频率之间的相关性。方法在性病门诊收集确诊的GH患者,记录病史及人口学资料并采集GH复发前后患者外周血,分别用放射免疫法及碱性磷酸酶-抗碱性磷酸(APAAP)法测定血清中PGI2水平及外周血CD4+、CD8+T淋巴细胞数量。SPSS软件分析GH复发频率与这些因素之间的相关性。结果GH患者复发频率同外周血清PGI2水平及病史分别呈高度正相关(R=0.884)和中度正相关(R=0.59);而与外周血CD4+/CD8+比值呈负相关(R=-0.445)。未发现疲劳、频繁性生活和刺激性食物同GH复发频率有明显的关系。结论GH的病程及外周血清PGI2水平是影响GH复发频率的相关因素,降低外周血PGI2水平可望减少GH的复发。

Objective To investigate the relationship among recurrence frequence of genital herpes （GH） and peripheral blood prostaglandin 12 （ PGI2 ） level so as to the ratio of CD4^＋/CD8^＋ of T lymphocyte subtype, Methods Patients with diagnosised GH in STD outpatient department were enrolled and their detail case history,behavior factors were record at their first visit. Blood samples were collected before and after treatment during GH relapse respectively for PGI2 detection by radio immunoassay and account for CD4^＋、CD8^＋ T lymphocyte by Alkaline Phosphatase-Anti-Alkaline Phosphatase technique （APAAP）, Relationship analy- sis was conducted with SPSS10.0 software. Results Positive relationship was showed between GH recurrence frequence and pe- ripheral PGI2 level, moderate positive relationship was showed as well between the case history of GH and its recurrence frequence, No relationship was showed between the behavior factors such as psychological stress, excess sex, tired and GH recurrence frequence. Conclusion Peripheral blood PGI2 level and history are factors to influence GH recurrence frequence, GH recurrence may decrease accompany with lower peripheral PGI2 concentration.