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抑癌基因的甲基化水平与胃癌的关系 被引量:2

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摘要 胃癌是一种严重威胁人类健康的恶性肿瘤,国内外大量资料显示,胃癌的发生与其他恶性肿瘤一样是多基因多阶段变异累积形成的病理过程,这些基因主要是促进肿瘤发生的癌基因和抑制肿瘤发生的抑癌基因,以及维持基因组稳定的DNA错配修复基因等。抑癌基因功能的丢失可通过多种途径,除基因突变和杂合性丢失以外还与其启动子发生甲基化修饰有关。
出处 《中华消化杂志》 CAS CSCD 北大核心 2007年第7期492-493,共2页 Chinese Journal of Digestion
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