广泛性临床下痫样放电的精神发育迟缓患儿抗癫痫治疗效果研究

Clinical effectiveness of antiepileptic therapy on generalized subclinical epileptiform discharges in infants with metal retardation

目的探讨广泛性临床下痫样放电的精神发育迟缓患儿抗癫痫治疗的效果。方法自2005年1月1日至2006年6月30日在我科确诊为广泛性临床下痫样放电的精神发育迟缓患儿50例,随机分成试验组和对照组,全部患儿接受脑营养药物、康复训练治疗,试验组添加丙戊酸钠,分别评估患儿在实验开始时和6个月后的认知发育水平,并检查自然睡眠脑电图。结果47例完成了本研究,于6个月时试验组脑电图改善显著较对照组满意(P<0.001),认知指数显著高于对照组(P<0.05)。结论对于广泛性临床下痫样放电的精神发育迟缓患儿,在康复训练的同时经积极抗癫痫治疗后,脑电图中癫痫样放电得到抑制,认知功能发育显著加快。

Objective To study the clinical effectiveness of antiepileptic therapy on generalized subclinical epileptiform discharges （SEDs） in infants with mental retardation. Methods A total of 50 mentally retarded infants, who were hospitalized in our hospital during Jan. 1^st, 2005 and Jun. 30^th, 2006 and definitely diagnosed as generalized SEDs, were randomly classified into the experimental and control groups. Sodium valproate oral solution was separately given to the experimental group, besides neurotrophic drugs and rehabilitation training to all infants; the level of cognitive development in all infants at baseline and at the sixth month of the experiment was assessed and their scalp electroencephalogram （EEG） of free sleep was examined. Results A total of 47 infants completed this study. The experimental group had obviously higher mental development index （MDI） （P〈0.05）, with significant reduction of epileptiform EEG discharges （P〈0.001） at the sixth month of the experiment, compared with that of the control group. Conclusion Antiepileptic therapy in addition to rehabilitation training, with the inhibition of epileptiform EEG discharges, development of cognitive function in the mentally retarded infants with generalized SEDs was obviously speeded up.