晚期胃癌的化学治疗

Chemotherapy for advanced gastric cancer

与最佳支持治疗对比，化疗对晚期胃癌有显著意义，但仍没有一个方案能明显优于其他方案而被广泛接受。新一代化疗药物如伊立替康、紫杉醇、多西紫杉醇、奥沙利铂、S-1、卡培他滨等的近期Ⅲ期临床研究显示进一步提高了疗效。分子靶向药物带来新的希望，是另一研究热点，它和细胞毒药物的联合应用也正在探索中。

When compared with best supportive care alone, combination chemotherapy yields a significant advantage in the management of advanced gastric cancer. However, no single regimen has emerged or been accepted as clearly superior to anothers. Ⅲ stage clinical trials of the new generation of agents such as irinotecan, paclitaxel, docetaxel, oxaliplatin, S- 1, capecitabine show more promising results. Molecular targeting agents are another concern to improve the treatment outcomes of this disease and are now under investigation in combination with conventional cytotoxic agents.