正常男女性兴奋的磁共振功能成像研究

An fMRI Study on Brain Activation Patterns of Males and Females During Video Sexual Stimulation

目的:利用磁共振功能成像技术探讨在色情录像刺激下正常男女性兴奋在中枢神经系统的差异。方法:健康男性和女性各20例,均为右利手,无性功能障碍史,无任何精神、心理及其他器质性疾病史。用色情录像和非色情录像刺激,每个录像片段60s,每个色情和非色情录像片段之间间隔12s。用GE1.5THD磁共振扫描系统进行血氧水平依赖的功能磁共振扫描,共扫描7.0min。用3DSPGR-T1WI序列进行全脑轴位扫描作为全脑解剖图。结果:在视听相关的性刺激下,男女激活不同的脑区:①女性双侧杏仁核激活,左侧激活体积为(220.52±17.09)mm3,右侧为(155.45±18.34)mm3,左侧明显大于右侧(P<0.05)。而男性仅左侧杏仁核被激活。②正常男性左前扣带回的激活较女性明显,男性左前扣带回激活体积为(420.75±19.37)mm3,女性为(310.67±10.53)mm3,两者差异有显著性(P<0.05);③女性胼胝体压部激活较男性明显(P<0.01),女性激活体积为(473.45±14.92)mm3,男性为(363.32±13.30)mm3。结论:男女性反应在中枢神经系统的激活存在差异,推测男女性脑结构和功能存在不同是这种差异的基础。

Objective： To investigate the difference in the brain activation patterns of males and females during video sexual stimulation by functional magnetic resonance imaging （fMRI）. Methods： The participants were 20 adult males and 20 adult females, all healthy, right-handed, and with no history of sexual function disorder and physical, psychiatric or neurological diseases. Blood-oxygen-level-dependent fMRI was performed using a 1.5 T MR scanner. Three-dimensional anatomical image of the entire brain were obtained by using a T1-weighted three-dimensional anatomical image spoiled gradient echo pulse sequence. Each person was shown neutral and erotic video sequences for 60 s each in a block-study fashion, i.e. neutral scenes - erotic scenes - neutral scenes, and so on. The total scanning time was approximately 7 minutes, with a 12 s interval between two subsequent video sequences in order to avoid any overlapping between erotic and neutral information. Results： The video sexual stimulation produced different results in the men and women. The females showed activation both in the left and the right amygdale, greater in the former than in the latter （ [ 220.52 ± 17.09 ] mm^3 vs [ 155.45 ± 18.34 ] mm^3, P 〈 0.05）, but in the males only the left amygdale was activated. The males showed greater brain activation than the females in the left anterior cingulate gyrus （ [420.75 ± 19.37 ] mm^3 vs [ 310.67 ± 10.53 ] mm^3, P 〈 0.05 ）, but less than the females in the splenium of the corpus callosum （ [ 363.32 ± 13.30 ] mm^3 vs [ 473.45 ± 14.92 ] mm^3, P 〈 0.01 ）. Conclusion ： Brain activation patterns of males and females during video sexual stimulation are different, underlying which is presumably the difference in both the structure and function of the brain between men and women.