Bio-Gide生物膜在单侧齿槽裂植骨的临床应用研究

The clinic study of autogenous bone grafting in unilateral cleft alveolar repair with Bio-Gide biomaterials

目的:将Bio-Gide生物膜覆盖单侧齿槽裂植骨区,观察植骨区新骨形成状况,探讨提高齿槽裂植骨效果的新方法。方法:选取65例无其他系统性疾病的单侧齿槽裂病例,随机分为单纯应用髂骨骨松质组和髂骨骨松质+Bio-Gide生物膜组。应用常规齿槽裂植骨手术方法,分别进行髂骨骨松质移植和Bio-Gide生物膜覆盖移植髂骨骨松质。手术后6个月随访,摄X线咬合片观察齿槽裂植骨区新骨生成,分别采用Witherow氏评分标准和Enemark氏评价标准,分析评价二种植骨方法在单侧齿槽裂修复中的疗效。结果:髂骨骨松质移植组Witherow氏植骨评分分值(4.84±1.78)低于髂骨骨松质移植+Bio-Gide生物膜组评分分值(6.05±2.16),有显著性差异(P<0.05)。根据Enemark氏评价标准,髂骨骨松质移植+Bio-Gide生物膜组齿槽裂植骨成活率(95.8%)及临床成功率(83.3%)均高于单纯应用髂骨骨松质移植组(85.4%及63.4%)。结论:Bio-Gide生物膜的应用能有效地提高齿槽裂髂骨骨松质移植的新骨形成。

Objective： To investigate the clinical effects of autogenous alveolar bone grafting （AABG） in cleft alveolar repair with Bio-Gide biomaterials. Method： A restrospective analysis was performed in a group of 65 unilateral cleft alveolar patients who received AABG. The patients were divided into A group using iliac bone graft,and B group using iliac bone graft covered with Bio-Gide biomaterials. All the patients have been followed up for 6 months postoperatively. The results of the bone grafting were evaluated on the radiograph. Result：The Witherow＇s alveolar bone graft scales in A group （4.84± 1.78） were significantly lower than B group （6.05±2.16）. According to Enemark＇s method, the overall survival rate and the clinical successful rate of AABG in B group were 95.8% and 83.3%, which were higher than A group （85.4% and 63.4%）. Conclusion： The clinical effects of AABG would be improved by Bio-Gide biomalerials.