脉压水平与冠状动脉病变的相关性

Correlation between coronary disease and pulse pressure

目的:探讨原发性高血压患者和正常血压者脉压水平与冠状动脉病变相关性。方法:将553例行冠状动脉造影的患者分为原发性高血压(高血压)组和正常血压组,再根据冠状动脉造影结果将2组再分为冠心病组和非冠心病组2个亚组,分别比较2组冠心病和非冠心病亚组之间脉压的水平,并将高血压组和正常高血压组不同脉压水平的患者冠心病的发生率进行比较,以探讨高血压患者和血压正常者冠心病的发生率与脉压的相关性。结果:不论高血压组和正常血压组,其冠心病亚组与非冠心病亚组比较,冠心病亚组脉压明显高于非冠心病亚组(P<0.05);脉压≥40mmHg(1mmHg=0.133kPa)患者冠心病发生率明显高于脉压<40mmHg患者(P<0.05)。结论:不论是否伴发高血压,脉压是冠心病发展的一个重要的、独立的预测指标,是冠心病发生发展的独立的危险因素。

Objective： To evaluate the relationship between coronary heart disease （CHD） and pulse pressure （PP） in patients with or without essential hypertension. Method：Five hundred and fifty-three cases of patients who underwent coronary angiography were divided into two groups： hypertensive group and normotensive group. Each group was divided into two subgroup： CHD and NCHD subgroup. PP was detected while the morbidity of CHD was evaluated in PP≥40 mmHg and PP〈40 mmHg subgroup. Result：PP of CHD subgroup is much higher than that of NCHD subgroup（P〈0.05） in either hypertensive or normotensive group; and the morbidity of CHD in PP≥40 mmHg subgroup is much higher than that of PP〈40 mmHg subgroup （P〈0.05）. Conclusion：PP is an independent and important predictor for development of CHD in either hypertensive or normotensive patients.