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p53基因敲除对细胞迁移的影响 被引量：1

Effect of p53 gene knockout on cell migration
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摘要 目的研究p53基因敲除对细胞迁移的影响。方法观察p53+/+和p53-/-细胞中血清诱导的板状伪足形成情况,以及利用Transwell细胞迁移系统观察p53基因敲除对血清诱导的细胞迁移的影响。结果在血清诱导下,p53+/+细胞能形成板状伪足和进行迁移,而p53-/-细胞中板状伪足的形成和细胞迁移都被阻断。结论p53在血清诱导的细胞迁移中具有重要作用。 Objective To investigate the role of p53 gene in serum-induced cell migration, Methods The effects of p53 knockout on serum-induced formation of lamellipodia and cell migration were observed using Transwell cell migration system, Results p53^＋/＋ cells developed lamellipodia upon serum stimulation and showed enhanced activity of cell migration, but these effects were not observed in p53 knockout cells after serum stimulation, Conclusion p53 plays a role in serum-induced cell migration.
作者 龚小卫 魏洁 李煜生 程蔚蔚 王旭 邓鹏 姜勇
机构地区 南方医科大学病理生理学教研室和广东省蛋白质组学重点实验室
出处 《南方医科大学学报》 CAS CSCD 北大核心 2007年第8期1132-1135,共4页 Journal of Southern Medical University
基金 广东省自然科学基金重点项目(13058) 广东省科技计划项目(A1090202) 广州市科技计划项目(2001-z-035-01-1)~~
关键词 P53 基因敲除 细胞迁移 p53 gene knockout cell migration
分类号 Q343 [生物学—遗传学]
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参考文献11

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同被引文献10

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南方医科大学学报
2007年 第8期

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