摘要
目的:将康复新制备成pH依赖和酶依赖2种结肠靶向微丸,使其在结肠定位释放,发挥局部治疗作用。方法:采用泛丸法制备素丸,流化床包衣技术对素丸进行包衣,分别对泛丸工艺和包衣参数进行了研究,筛选出最佳成型及包衣工艺。结果:微丸制备为干浸膏加125%淀粉+2%羧甲基纤维素钠,以30%乙醇为黏合剂,应用泛丸法制得素丸;制备得由Eudragit S100包衣得到的pH依赖及由果胶-羟丙基甲基纤维素(HPMC)包衣制得的酶依赖结肠靶向微丸。结论:制备得到了pH依赖和酶依赖2种康复新结肠靶向微丸。
Objective: To prepare coated micro-pellets of pH-dependent and enzyme-dependent Kangfuxin colon targeting delivery system, to make them go to colon, then release, educe partial effect. Method: We eploy pan-pill to prepare simple pellets, and prepare tunicatus pellets with fluidzed bed coating. We investigated the preparation and parameter of pellets, so, we bolting the best shaping and tunicatus artwork. Result: The ingredients for preparing the micro-pellets are 125% starch +2% CMC-Na, and add 30% ethanol to be binder, pellets were coated with Eudragit S100 to prepare ph-dependent and pectin-HPMC to prepare enzyme-dependent colon targeting micro-pellets. Conclusion: We get two micro-pellets of pH-dependent and enzyme-dependent Kangfuxin colon targeting.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第15期1529-1532,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30371780)
关键词
康复新
结肠靶向
微丸
制备工艺
kangfuxin
colon targeting
micr-pellets
prep-technology