冬虫夏草软胶囊改善支气管哮喘患者气道炎症的临床研究

Effect of Dongchong Xiacao capsule on airway inflammation of asthmatic patients

目的:观察冬虫夏草软胶囊对支气管哮喘患者气道炎症的改善作用,探索中医补益肺肾法对哮喘患者治疗作用的相关机制。方法:将60例符合纳入标准的支气管哮喘患者随机分为治疗组(30例)和对照组(30例)。对照组以吸入激素+短效支气管扩张剂治疗,治疗组在此治疗的基础上加用冬虫夏草软胶囊。疗程2个月。检测治疗前后患者血清中的相关炎症指标IL-4,IFN-γ,sICAM-1,MMP-9,IgG,IgE。结果:治疗组治疗后血清IgG升高,IgE,sICAM-1,IL-4,MMP-9明显降低。两组间比较,治疗组对IgE,sICAM-1,IL-4,MMP-9的改善优于对照组(P<0.05,P<0.01)。对IgG,IFN-γ的改善两组间差别未产生统计学意义。结论:冬虫夏草软胶囊可能通过调节TH1/TH2的平衡,减少IL-4的分泌,降低黏附分子的表达,抑制炎性细胞的黏附和跨内膜转移,减少IgE合成,从而减轻气道炎症,缓解哮喘症状。该药物还可能具有一定的改善气道重构的作用。

Objective： To investigate the effect of Dongchong Xiacao capsule on the airway inflammation of asthmatic patiems and to explore the relevant mechanism of therapeutic effect of Dongchongxiacao capsule. Method： Sixty patients with moderate persistent asthma were randomized into the treatment group （n = 30） and the control group （n = 30）. Inhaled corticosteroid and as-needed β-agonist were used in the treatment group while this therapy plus Dongchong Xiacao capsule were used in the control group for two months. Serum IL-4, IFN-γ, sICAM-1, MMP-9, IgG, IgE level were assessed at randomization and 2 months after randomization. Result： The serum level of IgE, slCAM-1, IL-4 and MMP-9 of the treatment group was lowered to a greater degree than that of the control group （P 〈 0. 05 or P 〈 0. 01 ）. Conclusion： Dongchong Xiacao capsule can reduce the serum markers of airway inflammation, which suggests this therapy bares the anti-inflammation effects probably through regulating the balance of TH1/TH2, inhibiting the activity of adherence molecule and reducing IgE production. It may also have the effect of reversing airway remodeling, which needs further research to determine.