国内丙型肝炎病毒感染与肝细胞癌关系的19个病例对照研究的 Meta 分析

Meta analysis of the Relation Between HCV Infection and HCC in China:Combined Analysis of 19 Case control studies

本文对国内１９个有关丙型肝炎病毒（ＨＣＶ）感染与肝细胞癌（ＨＣＣ）关系的病例对照研究进行Ｍｅｔａ分析。经齐性检验表明，１９个研究中有１７个研究结果是一致的。对此１７个研究结果加权合并，累积ＨＣＣ病例１５７７例，ＨＣＶ感染率为２３．０％，累积对照１９８０例，ＨＣＶ感染率为４．０％；合并ＯＲ值为６．７。结果表明，国内ＨＣＶ感染与ＨＣＣ关系密切，ＨＣＶ感染是ＨＣＣ发生的一个危险因素。

In the present paper,19 case control studies on the relation between hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) in China were analyzed by means of Meta analysis.It was showen that 17 or 19 studies were hemogenous by means of hemogenity test.These 17 studies were weighted and pooled.The cumulative cases were 1557.the prevalence of HCV was 23 0%.The cumulative controls were 1980,the prevalence of HCV was 4 0%.The pooled OR value was 6 7.The results showed that there was close correlation between HCV infection and HCC in China.HCV infection was a risk factor for HCC development.