摘要
目的：观察转化生长因子-β1（TGF-β1）在宫颈鳞状细胞癌组织中的表达情况,探讨其与宫颈癌发生发展的关系,明确其表达的意义。方法：应用免疫组化SP法检测40例宫颈鳞状细胞癌组织（病理分级Ⅰ~Ⅲ级）中TGF-β1蛋白的表达,与正常宫颈组织及慢性宫颈炎组织中的表达作定量比较。结果：①正常宫颈组织及慢性宫颈炎组织中TGF-β1表达位于上皮细胞的胞浆内,两组表达水平无显著性差异（P〉0.05）;宫颈鳞状细胞癌中TGF-β1表达位于癌细胞的胞浆内。②宫颈鳞状细胞癌中TGF-β1表达水平明显上升,与正常宫颈组织及慢性宫颈炎组织比较有极显著性差异（P〈0.01）。③随着宫颈癌病理分级的增加,TGF-β1表达水平逐步上升,有显著性差异（P〈0.05）。结论：本研究提示宫颈鳞状细胞癌的发生发展可能与TGF-β1的高表达有关。
Objective： To observe the expression of TGF - β1 protein in human cervical squamous cancinoma and investigate the possible role of TGF- β1 in facilitating neoplastic progression and try to clear the value of the expression of TGF- β1 protein. Methods： The expression of TGF - β1 protein in human cervical squamous carcinoma was examined by the streptavidin - peroxidase （ S - P） immunohist - chemical method, and their contents were compared with those of normal cervical tissues and chronic cervicitis tissues. Results： （1）TGF - β1 protein were expressed in the cytoplasm of squamous cells and malignant cells, no difference of their contents existed between normal cervical tissues and chronic cervicitis tissues （ P 〉 0. 05 ） ; （2）The expression of TGF - β1 protein in cervical squamous carcinoma were significantly higher than those in normal tissues and chronic cervicitis tissues （ P 〈 0. 01 ） ; （3）The expression of TGF - β1 was positively correlated with the pathologic grade. Conclusion： The high - expression of TGF -β1 protein might play an important role in tumor genesis and the development of cervical squamous carcinoma.
出处
《中国妇幼保健》
CAS
北大核心
2007年第24期3423-3425,共3页
Maternal and Child Health Care of China
