曲马多复合芬太尼用于食管癌术后止痛临床观察

Clinical observation on the effect of tramadol combined with fentanyl in postoperative analgesia for esophageal cancer patients

目的选择一种用于食管癌安全且有效的静脉术后止痛方法。方法随机选取60例食管癌患者分为两组。T组(曲马多0.3mg·kg-·h-+芬太尼0.25mg·kg-·h-),M组(吗啡0.014mg·kg-·h-)。比较VAS及不良反应。结果两组患者在术后72h中VAS评分基本为良好,止痛效果均较好,P>0.05,无显著性差异;其中恶心、呼吸抑制及低血压这三种副反应的发生率也无显著性差异,P>0.05;皮肤瘙痒、尿潴留和呕吐等不良反应在M组比T组要显著增多,P<0.05,其发生率在M组依次为23.33%、23.33%和30%,在T组依次为0、6.67%和13.33%。结论曲马多配伍芬太尼用于食管癌手术后止痛是安全和有效的。

Objective To choose a safe and effective intravenous postoperative analgesia method for esophageal cancer patient. Methods Sixty cases of esophageal cancer patients were divided randomly into 2 groups：T group （Tramadol 0.3mg·kg^-·h^-＋Fentanyl 0.25 mg·kg^-·h^-）,and M group（Morphine 0.014 mg·kg^-·h^-）.VAS and side effect were analysed. Results Analgesia effect （VAS）in the period of 72h postoperative were preferable in both two groups,with no significant difference between them（P〉0.05）.Incidence of nausea,respiratory suppression and hypotension had no significant difference between the two groups （P〉0.05）.While incidence of dermal pruritus,uroschesis and vomit in M group were higher than those in T group （P〈0.05）,with 23.33%,23.33% and 30% in M group ,and 0,6.67% and 13.33% in T group respectively. Conclusion Tramadol combined with Fentanyl is safe and effective in postoperative analgesia for esophageal cancer patient.