糖皮质激素受体阻断对烫伤大鼠肺、肾功能及其血管壁通透性的影响

Effects of Glucocorticoid Receptor Blockade on Pulmonary and Renal Function and Vascular Permeability in Scalded Rats

目的：进一步阐明烧伤后糖皮质激素受体（ＧＲ）减少的意义．方法：以ＲＵ３８４８６阻断大鼠体内的ＧＲ，通过检测其肺、肾组织匀浆中异硫氰酸荧光素钠（ＦＩＴＣ）标记白蛋白的渗出量测定大鼠肺、肾血管壁通透性．结果：烫伤阻断组大鼠肺、肾功能衰竭的发生率及其组织匀浆中ＦＩＴＣ标记白蛋白渗出量均明显高于单纯烫伤组（Ｐ＜０．０５）．结论：ＧＲ阻断可加重烫伤大鼠肺、肾血管壁通透性的升高，并由此导致肺、肾功能衰竭．

Aim: To further expound the significance of glucocorticoid receptor (GR) decrease in scald. Methods: With GR blockade by RU38486, the change in contents of albumin labled with FITC (FITC albumin) in pulmonary and renal tissue homogenate was measured to study the change in vascular permeability in rats. Results: The occurrence of respiratory and renal failure in scalded rats accompanied by GR blockade was much more frequent than that in the rats with scald only ( P <0.05), and the contents of FITC albumin in pulmonary and renal tissue homogenate in the scalded rats accompanied by GR blockade were significantly higher than those in the rats with scald only ( P <0.05). Conclusion: GR blockade might aggravate the increase of vascular permeability caused by scald, thus resulting in respiratory and renal failure.