C反应蛋白水平与冠心病的相关性研究

Relationship Between C Reactive Protein Level and Severity of Coronary Heart Disease

目的探讨冠状动脉粥样硬化心脏病(CHD)与C反应蛋白(CRP)之间的关系。方法测定50例正常对照人群和80例经冠状动脉造影证实为CHD患者血浆的CRP水平,其中单支病变30例、双支病变25例、三支病变25例;稳定型心绞痛31例、不稳定型心绞痛25例,急性心肌梗死24例。结果CRP水平在稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组依次增高;稳定型心绞痛组(F=1.826,P<0.05)、不稳定型心绞痛组(F=4.232,P<0.01)及急性心肌梗死组(F=6.745,P<0.01)的CRP水平均明显高于对照组,在冠心病组中,双支病变组(F=7.925,P<0.01)以及三支病变组(F=9.467,P<0.01)中CRP水平也明显高于对照组。结论CRP水平与冠心病和冠脉病变程度相关。

Objective To explore the relationship between coronary heart disease （ CHD ） and C reactive protein （CRP） level. Methods The level of CRP was measured in 80 CHD patients confirmed by coronary angiography （CAG） and compared with the level of 50 healthy controls. In the CHD group, there were 31 patients wtih stable angina, 25 patients wtih unstable angina and 24 patients with acute myocardial infarction; there were 30 patients with single vessel pathological changes and 50 patients with more than single vessel pathological changes. Results The plasma CRP levels increased sequentially in the stable angina pectoris group, the unstable angina pectoris group and acute myocardial infarction group. The indices of the stable angina pectoris group （ F = 1. 826, P 〈 0. 05 ）, the unstable angina pectoris group （ F = 4. 232, P 〈 0. 01 ） and acute myocardial infarction group（ F =6. 745, P 〈0.01} were significantly higher than those of the normal control group. In the coronary heart disease group, the CRP level of 2 vessels lesion group F = 7. 925, P 〈 0.01 ） and 3 vessels lesion group （ F = 9. 467, P 〈 0.01 ） were increased sequentially, and were significantly higher than those in the normal control group. Conclusions The CRP level are correlative with CHD and the severity of CHD.