摘要
A novel platinum complex,named as saliplatin,was designed,synthesized and characterized with element analysis,coupled inductively plasma-mass spectrum,gravitational thermal-differential thermal analysis,ultraviolet-visible absorption spectrum,infrared spectrum,fast atom bombment mass spectrum and 1H NMR,etc.Its purity was investigated and determined.HPLC-ESI-MS was employed to separate the platinum complex and the impurity,and to identify and quantify the latter.It proved that the impurity in this novel compound was 3,5-diisopropylsalycilic acid,a reactant used in the synthesis of the novel platinum complex,identified with ESI-MS.The mass fraction was determined with HPLC as 4.3%,which meant that the purity of this new substance was 95.7%.
A novel platinum complex, named as saliplatin, was designed, synthesized and characterized with element analysis, coupled inductively plasma-mass spectrum, gravitational thermal-differential thermal analysis, ultraviolet-visible absorption spectrum, infrared spectrum, fast atom bombment mass spectrum and I H NMR, etc. Its purity was investigated and determined. HPLC-ESI-MS was employed to separate the platinum complex and the impurity, and to identify and quantify the latter. It proved that the impurity in this novel compound was 3,5-diisopropylsalycilic acid, a reactant used in the synthesis of the novel platinum complex, identified with ESI-MS. The mass fraction was determined with HPLC as 4. 3%, which meant that the purity of this new substance was 95.7%.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2007年第8期1486-1488,共3页
Chemical Journal of Chinese Universities
基金
清华大学裕元医学研究基金(批准号:20240000529)资助
