VEGF在膀胱移行细胞癌中的表达及临床意义

Expression of VEGF in Human Transitional Cell Carcinoma of Bladder and Its Clinical Significance

目的:探讨血管内皮生长因子(VEGF)在膀胱移行细胞癌中的表达及临床意义。方法:采用免疫组化、ELISA方法对45例膀胱移行细胞癌组织、血浆和10例正常膀胱黏膜组织、30例正常成人血浆中VEGF进行检测分析。结果:VEGF在膀胱移行细胞癌患者中呈高表达,且随分期、分级的增高而增高;膀胱癌手术前患者血浆中VEGF的浓度高于手术后。结论:1.VEGF的表达与膀胱移行细胞癌的病理分级、临床分期及生物学行为有密切关系;2.血浆中VEGF水平可有助于预测膀胱癌患者手术疗效。

Objective To investigate the expression of VEGF in human transitional cell careionoma of bladder（BTCC） and discuss its clinical significance. Methods Using immunohistochemical stains and enzyme-Linked immunosorbent assay , the expression of VEGF of 45 cases of bladder carcinoma tissue , plasma （tumor group） and 10 cases of normal bladder tissue, 30 normal adult plasmas were analyzed. Results VEGF was highly expressed in tumor samples and its expression rates increased with grades and stages. The plasma VEGF concentration of BTCC group before operation was higher than that of after operation. Conclusion 1. Expression of VEGF has a close relationship with pathology graduation, clinical by stages and Biology behavior of BTCC; 2. In the blood plasma the VEGF level may be helpful to the forecast carcinoma of bladder patient surgery curative effect.