肺炎衣原体与急性心梗、心绞痛型冠心病的关系

Investigating the Relationship between Chlamydia Pneumoniae and Acute Myocardio Infarction or Angina in CHD Patients

目的:探讨肺炎衣原体(TWAR)与急性心梗(AMI)、心绞痛(Angina)型冠心病之间的关系。方法:采用多聚合酶链反应(PCR)技术对200例冠心病(急性心梗56例,不稳定心绞痛124例,稳定心绞痛20例)和180例非冠心病患者进行全血标本肺炎衣原体DNA检测。结果:急性心梗组肺炎衣原体DNA阳性率为73.2%,不稳定心绞痛组为52.4%,稳定心绞痛组为45.0%;对照组为21.1%,三组与对照组相比,差异均有显著性(P<0.01,P<0.01,P<0.05)。结论:肺炎衣原体感染与急性心梗、心绞痛型冠心病存在密切关系。

Objective： To investigate the relationship between chlamydia pneumoniae（TWAR） and coronary heart disease （CHD） with acute myocardio infarction or angina. Methods： By means of polymerase chain reaction（PCR） ,TWAR nucleic acid was detected in 56 patients with acute myocardio infarction, 124 patients with unstable angina,stable angina;and 180 control subjects. Results： The positive rates of TWAR-DNA were 73.2%,52.4%,45.0% in the AMI,unstable angina,stable angina patients and 21.1% in the control group respectively;which showed significant difference （P〈0. 01 ,P〈0.01,P〈0.05）. Conclusion： TWAR infection is closely connected with CHD （acute myocardio infarction or angina） ,and may be one of the risk factors in CHD mechanisms.