锶羟基磷灰石生物活性骨水泥应用于髋关节置换的研究

In vitro and in vivo evaluation of strontium-containing hydroxyapatite in hip replacement

目的探讨锶羟基磷灰石（St-HA）生物活性骨水泥应用于髋关节置换的可行性。方法对Sr—HA生物活性骨水泥的力学特性及其在体应用于髋关节置换及髋关节翻修的生物学特性与聚甲基丙烯酸甲酯（PMMA）骨水泥进行比较及评价。结果Sr-HA生物活性骨水泥与PMMA骨水泥抗压缩强度相似，但其断裂韧度却高于PMMA骨水泥；在体研究表明Sr-HA生物活性骨水泥能与骨形成骨性融合，其与骨界面的剪切力明显大于PMMA骨水泥。结论Sr—HA生物活性骨水泥具有替代PMMA骨水泥应用于髋关节置换的潜力。

Objective To assess the possibility of using strontium-containing hydroxyapatite （Sr-HA） bioactive bone cement in hip replacement. Methods The mechanical properties of Sr-HA bone cement were measured, and its in vivo uses in the hip replacement and the revision of hip replacement were investigated respectively. Results The compression strength of Sr-HA cement was similar to that of PMMA bone cement, but its fracture toughness was much higher than that of the latter. In vivo studies showed that Sr-HA bone cement could form osteointegration with bone and the shear stress between bone and Sr-HA cement was much higher than that between bone and PMMA. Conclusion It is possible to substitute Sr-HA bone cement for PMMA bone cement in hip replacement.