应用血清铁蛋白与运铁蛋白受体比值评价儿童铁营养状况

Evaluation of Iron Supplementation Effects in Children by Ratio of Serum Transferrin Receptor to Serum Ferritin

目的利用运铁蛋白受体、血清运铁蛋白受体与血清铁蛋白比值评价儿童铁补充干预效果。方法选择某幼儿园3-6岁健康儿童,按班随机分为3组,A组为每日补充组（一周补充5次微量营养素补充剂）、B组为间歇性补充组（每周补充一次微量营养素补充剂）、C组为空白对照组。从3组儿童中,每组随机抽取30名儿童,测定干预前后血清铁蛋白（SF）和运铁蛋白受体（sTfR）含量,并计算运铁蛋白受体含量与血清铁蛋白含量比值（RF）和机体铁含量（BFe）。结果干预前,三组儿童的sTfR、SF、RF、BFe含量差异无统计学意义（P〉0.05）。干预后,A、B组儿童的sTfR、RF显著降低,BFe含量显著升高,而C组儿童的sTfR、RF、BFe无明显变化（P〉0.05）;干预后,A组、B组儿童的sTfR、RF显著低于C组（P〈0.05）,BFe含量显著高于C组（P〈0.05）;A组与B组之间sTfR、BFe含量及RF比值差异无统计学意义（P〉0.05）。结论血清运铁蛋白受体含量与血清铁蛋白比值以及计算出的机体铁含量能够很好地用于评价儿童铁干预效果。

Objective To evaluate the effects of Serum Transferrin Receptor （sTiR） and the ratio of TIR to Serum Ferritin （SF） on the assessment of iron status in children. Methods Healthy children aged 3- 6 years from a rindergarten were divided into three groups randomly. Group A received iron supplement five times a week, Group B once a week and Group C received placebo for 13 weeks. The levels of SF, sTiR, sTiR： ST and BFe before and after intervention were measured in 90 children selected from the three groups respectively. Results After intervention, in two intervention groups, the levels of sTiR and RF decreased significantly and the level of BFe increased significantly. There were no significant difference between group A and group B in sTiR, BFe and sTiR： SF. Conclusion sTiR：SF and BFe can be used to evaluate the effects of iron Supplementation.