锌指蛋白2在胰腺癌中的表达

Expression of hematopoietic zinc finger 2 gene in pancreatic cancer.

目的对锌指蛋白2（HZF2）在胰腺癌中的表达及意义进行初步的探讨。方法收集20例手术病理证实的胰腺癌标本,应用RT-PCR检测锌指蛋白基因HZF2 mRNA的表达,并分析该表达与胰腺癌临床病理特征的关系。结果胰腺癌组织中HZF2 mRNA表达值平均为143.1±12.2,较相应癌旁组织表达值82.2±7.6高1.40-2.34倍（P〈0.01）。HZF2 mRNA的表达与TNM分期呈正相关,而与性别、肿瘤部位、肿瘤大小、分化程度无关。结论锌指蛋白2在胰腺癌中高表达,在胰腺癌的发生发展中可能起一定作用。

Objective To investigate the expression and clinical significance of human zinc finger 2 （HZF2） in pancreatic cancer. Methods The expression levels of HZF2 mRNA in 20 cases of pancreatic cancer which were confirmed by surgery and pathological evidence and tissues adjacent to the cancers were measured by RT-PCR. The potential association between the expression of HZF2 and the clinicopathological features of pancreatic cancer was explored. Results Compared with tissues adjacent to cancers （mean score of HZF2 mRNA expression： 82.2 ±7.6）, HZF2 expressions were remarkably up-regulated in 20 pancreatic cancers with a 1.40 to 2, 34 fold increment （mean score： 143. 1 ±12.2） （P 〈0.01）. HZF2 mRNA levels were positively correlated with TNM staging. But it was not correlated with gender, location of tumor, tumor size, and differential degree. Conclusions HZF2 gene was highly expressed in pancreatic cancer and may play a role in the development of pancreatic cancer.